Identification of ONECUT3 as a Stemness-Related Transcription Factor Regulating NK Cell-Mediated Immune Evasion in Pancreatic Cancer

Researchers found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.