Survivin as a Mediator of Stiffness-Induced Cell Cycle Progression and Proliferation of Vascular Smooth Muscle Cells

Investigators performed analyses of whole-transcriptome microarray data from mouse vascular smooth muscle cells (VSMCs) cultured on stiff hydrogels simulating arterial pathology that identified 623 genes that were significantly and differentially expressed relative to expression in VSMCs cultured on soft hydrogels.