Functional Dissection of PRC1 Subunits RYBP and YAF2 During Neural Differentiation of Embryonic Stem Cells

The authors showed that the expression of RYBP and YAF2 decreased and increased, respectively, during neural differentiation of ESCs. Rybp knockout impaired neural differentiation by activating Wnt signaling and derepressing nonneuroectoderm-associated genes.