Small Cell Lung Cancer Plasticity Enables NFIB-Independent Metastasis
Using conditional gene knockout strategies in genetically engineered mouse models o small cell lung cancer, investigators found that upregulation of NFIB contributed to tumor progression, but NFIB was not required for metastasis
[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.
[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.
[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.