Dual Targeting of MAPK and PI3K Pathways Unlocks Redifferentiation of Braf-Mutated Thyroid Cancer Organoids

[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.

[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.

[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.