Human Fetal Tissue Is Critical for Biomedical Research
The authors increased functionality of cells derived from fetal tissues arises from increased proliferative capacity, ability to survive in culture, and developmental potential that is attenuated in adult tissues.
[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.
[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.
[Nature Reviews Drug Discovery] Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.