Clonal Selection of Hematopoietic Stem Cells after Gene Therapy for Sickle Cell Disease
Researchers used whole-genome sequencing to track HSCs from six patients with sickle cell disease at pre- and post-Gene therapy time points to map the somatic mutation and clonal landscape of gene-modified and unmodified HSCs.
[FDA] The FDA has received reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies.
[Nature Biomedical Engineering] Investigators showed that replacement of the extracellular domains of heterodimeric cytokine receptors in T cells with two leucine zipper motifs provided optimal Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling.
[blood] The authors presented the clinicogenomic characterization of a CARTITUDE-4 patient who developed a CAR+ T cell lymphoma post cilta-cel. Diagnostic and staging workup included biopsy analyses and FDG-PET scan.