E3 Ligase Trim35 Inhibits LSD1 Demethylase Activity through K63-Linked Ubiquitination and Enhances Anti-Tumor Immunity in NSCLC

Combinational use of a lysine-specific histone demethylase 1A (LSD1) inhibitor and anti-PD-1 therapy could significantly eradicate poorly immunogenic lung cancer with low Trim35.