Hallmarks of Aging in Human Skeletal Muscle and Implications for Understanding the Pathophysiology of Sarcopenia in Women and Men

Scientists evaluate how the nine classic hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication contribute to skeletal muscle aging and the pathophysiology of sarcopenia.