CAR⁺ and CAR⁻ T Cells Share a Differentiation Trajectory into an NK-Like Subset after CD19 CAR T Cell Infusion in Patients with B Cell Malignancies

Investigators conducted a single-cell multi-omics analysis of transcriptional, clonal, and phenotypic profiles from pre- to one-month post-infusion of CAR+ and CAR− T cells from patients from a CARTELL study who received a donor-derived 4-1BB CAR product targeting CD19.