The DNA/RNA Helicase DHX9 Orchestrates the KDM2B-Mediated Transcriptional Regulation of YAP1 in Ewing Sarcoma

Transcriptome profiling combined to bioinformatic analyses disclosed a gene signature commonly regulated by DHX9 and the lysine demethylase KDM2B, with the Hippo pathway regulator YAP1 as a prominent target in Ewing sarcoma.