Epigenetic Switch Reshapes Epithelial Progenitor Cell Signatures and Drives Inflammatory Pathogenesis in Hidradenitis Suppurativa

Researchers investigated hidradenitis suppurativa epithelial cells and demonstrated that hidradenitis suppurativa basal progenitors modulated their lineage restriction and gave rise to pathogenic keratinocyte clones, resulting in epidermal hyperproliferation and dysregulated inflammation.