SRSF2 Mutation Reduces Polycythemia and Impairs Hematopoietic Progenitor Functions in JAK2V617F-Driven Myeloproliferative Neoplasm

Scientists showed that co-expression of Srsf2P95H mutant reduced red blood cell, neutrophil, and platelet counts,and attenuated splenomegaly, but did not induce bone marrow fibrosis in the Jak2V617F/+ mice.