Deletion of Mettl3 in Mesenchymal Stem Cells Promotes Acute Myeloid Leukemia Resistance to Chemotherapy

Researchers evaluated the methyltransferase-like 3 (METTL3) function in vivo. Mice exhibiting a conditional removal of Mettl3 in bone marrow MSCs were developed by mating Prrx1-CreERT2;Mettl3fl/+ mice with Mettl3fl/fl mice using the CRISPR-Cas9 system.