Modeling Cardiac Fibroblast Heterogeneity from Human Pluripotent Stem Cell-Derived Epicardial Cells

Researchers demonstrated that their system models the early interactions between epicardial cells and cardiomyocytes to generate a population of fibroblasts that recapitulates many aspects of fibroblast behavior in vivo, including changes associated with maturation and in response to pathological stimuli associated with cardiac injury.