Silencing hsa_circ_0032449 Inhibits the Pancreatic Differentiation of Human Embryonic Stem Cells via the hsa_miR-195-5p/CCND1/PI3K/AKT Signaling Pathway

Pancreatic specification is essential for stem cell-derived β cells cell induction in vitro and low-quality pancreatic progenitor (PP) cells may convert into derivatives of non-pancreatic lineages both in vivo and in vitro, impeding PP-derived β cell safety and differentiation efficiency.