Cepharanthine, a Regulator of keap1-Nrf2, Inhibits Gastric Cancer Growth Through Oxidative Stress and Energy Metabolism Pathway

Cepharanthine (CEP) inhibited the cellular activity of gastric cancer AGS, HGC27 and MFC cell lines in this study. CEP-induced apoptosis reduced Bcl-2 expression and increased cleaved caspase 3, cleaved caspase 9, Bax, and Bad expression.