Presenilin-1 in Smooth Muscle Cells Facilitates Hypermuscularization in Elastin Aortopathy

Genetic approaches revealed that endothelial cell-specific presenilin (Psen)-1 deletion did not improve elastin aortopathy whereas deletion of either Psen1 in smooth muscle cells (SMCs) or Psen2 globally attenuated Notch pathway and SMC proliferation, mitigating aortic disease.