Amyloid-β Specific Regulatory T Cells Attenuate Alzheimer’s Disease Pathobiology in APP/PS1 Mice

TCRAβ -Tregs were generated by CRISPR-Cas9 knockout of endogenous T cell receptor (TCR) and consequent incorporation of the transgenic TCRAb identified from amyloid-beta (Aβ) reactive Teff monoclones.