Human Retinal Organoids with an OPA1 Mutation Are Defective in Retinal Ganglion Cell Differentiation and Function

The authors generated isogenic iPSCs carrying the hotspot OPA1 c.2708_2711delTTAG mutation and found that the mutant variant caused defective initial and terminal differentiation and abnormal electrophysiological properties of organoid-derived retinal ganglion cells.