The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation

Through biochemical analysis of RNA:protein interactions, investigators uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (Malat1) and the microRNA family miR-15/16.