The Characteristics and Function of Small Extracellular Vesicles Derived from Bone Marrow and Umbilical Cord Mesenchymal Stromal Cells Are Influenced by Cell Culture Conditions

Researchers compared extracellular vesicles isolated from two tissue sources of MSCs that were exposed to various cell culture conditions and evaluated their anti-inflammatory effects. Bone marrow and umbilical cord-derived MSCs were exposed to either a serum-free media environment, an inflammatory environment or media supplemented with 5% EV depleted fetal bovine serum.