Increased Activity of MAPKAPK2 Within Mesenchymal Cells as a Target for Inflammation Associated Fibrosis in Crohn’s Disease

Investigators evaluated cell-specific changes in MAPKAPK2 (MK2) activity between predominantly inflammatory Crohn’s disease (CD) versus CD with fibrotic complication and defined the role of stromal cell-specific MK2 activation in CD-associated. CD tissue, CD tissue-derived MSCs, fibroblast specific MK2 conditional knockout mice were used.