Tumor Resistance to Anti-Mesothelin CAR-T Cells Caused by Binding to Shed Mesothelin Is Overcome by Targeting a Juxtamembrane Epitope

Scientists developed an antibody (15B6) that bound next to the membrane at the protease-sensitive region, did not bind to shed mesothelin, and made CAR-T cells that had much higher anti-tumor activity than a CAR-T that binds to shed mesothelin.