Brg1/PRMT5 Nuclear Complex Epigenetically Regulates FOXO1 in IPF Mesenchymal Progenitor Cells

Investigators hypothesized that a Brg1/PRMT5 nuclear complex epigenetically regulates critical nodes in idiopathic pulmonary fibrosis mesenchymal progenitor cell (IPF MPC) self-renewal signaling networks. IPF and control MPCs were isolated from primary mesenchymal cell lines established from IPF and control patients.