Inhibition of Protein Kinase C Increases Prdm14 Level to Promote Self-Renewal of Embryonic Stem Cells Through Reducing Suv39h-Induced H3K9 Methylation

Administration of Go6983 increased Prdm14 expression mainly through the inhibition of PKCδ. High constitutive expression of Prdm14 phenocopied the ability of Go6983 to maintain` mouse ESC stemness in the absence of self-renewal-promoting cytokines.