GNAS Mutation Inhibits Growth and Induces Phosphodiesterase 4D Expression in Colorectal Cancer Cell Lines

0
28
The authors investigated the effect of an activating GNAS mutation in colorectal cancer cell lines on gene expression and cell proliferation in vitro, and tumor growth in vivo. GNAS-mutated HCT116 cells showed stimulated synthesis of cAMP as compared to parental cells.
[International Journal of Cancer]
Full Article