Phosphatase, Mg²⁺/Mn²⁺ Dependent 1B Regulates the Hematopoietic Stem Cells Homeostasis via the Wnt/β-Catenin Signaling

By using a conditional knockout mouse model in which Ppm1b was specifically depleted in hematopoietic cells, researchers demonstrated that loss of Ppm1b impaired the HSC homeostasis and hematopoietic reconstitution.