Phosphatase, Mg2+/Mn2+ Dependent 1B Regulates the Hematopoietic Stem Cells Homeostasis via the Wnt/β-Catenin Signaling

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By using a conditional knockout mouse model in which Ppm1b was specifically depleted in hematopoietic cells, researchers demonstrated that loss of Ppm1b impaired the HSC homeostasis and hematopoietic reconstitution.
[Haematologica]
Abstract