Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

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Scientists constructed CD38 antigen receptor membrane-modified MSC-extracellular vesicles by transfecting MSCs with a lentivirus loaded with a CD38 antigen receptor–CD8 transmembrane fragment fusion plasmid to target AEC2s and alleviate pulmonary fibrosis.
[ACS Nano]
Abstract