Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

Scientists constructed CD38 antigen receptor membrane-modified MSC-extracellular vesicles by transfecting MSCs with a lentivirus loaded with a CD38 antigen receptor–CD8 transmembrane fragment fusion plasmid to target AEC2s and alleviate pulmonary fibrosis.