Biofabrication of Biomimetic Undulating Microtopography at the Dermal-Epidermal Junction and Its Effects on the Growth and Differentiation of Epidermal Cells

A composite manufacturing method including electrospinning, 3D printing, and functional coating was developed to produce the epidermal models with rete ridges. Polycaprolactone nanofibers were firstly electrospun to mimic the extracellular matrix environment and be responsible for cell attachment.