Integrative Single-Cell Expression and Functional Studies Unravels a Sensitization to Cytarabine-Based Chemotherapy Through HIF Pathway Inhibition in AML Leukemia Stem Cells

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Scientists identified HIFhigh and HIFlow specific AML subgroups and provided a comprehensive single-cell expression atlas of 119,000 AML cells and AML-leukemia stem cells in paired diagnostic-relapse samples from these molecular subgroups.
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