YES1 as a Potential Target to Overcome Drug Resistance in EGFR-Deregulated Non-small Cell Lung Cancer

The authors investigated the expression and functional role of YES1, one of the Src-family kinases, in epidermal growth factor receptor(EGFR)-TKI-resistant NSCLC. YES1 expression was elevated in gefitinib-resistant HCC827 cells, harboring EGFR mutations.