Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment

To improve the therapeutic efficiencies of MSCs in osteoarthritis treatment by carbonic anhydrase IX siRNA-based inflammation regulation and Kartogenin-based chondrogenic differentiation, the combination strategy of MSCs and the nanomedicine codelivering KGN and siCA9 was used.