Osteomacs Promote Maintenance of Murine Hematopoiesis Through Megakaryocyte-Induced Upregulation of Embigin and CD166

The authors characterized osteomacs (OMs) and identify megakaryocyte-induced mediators that augment the role of OM in the niche. Single-cell mRNA-seq, mass spectrometry, and CyTOF examination of megakaryocyte-stimulated OM suggested that upregulation of CD166 and Embigin on OM augment their hematopoiesis maintenance function.