MLL1 Regulates Cytokine-Driven Cell Migration and Metastasis

MLL1, with its scaffold protein Menin, controlled actin filament assembly via the IL-6/8/pSTAT3/Arp3 axis and myosin contractility via the TGF-β1/Gli2/ROCK1/2/pMLC2 axis, which together regulated dynamic protrusion generation and 3D cell migration.