Directed Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Sustained Release of BMP4 From PBVHx-Based Nanoparticles

To enhance its osteogenic activity while reducing dosage and administration frequency, investigators developed a novel long-acting BMP4 delivery system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PBVHx) nanoparticles with soybean lecithin-modified BMP4.