cDC2 Plasticity and Acquisition of a DC3-Like Phenotype Mediated by IL-6 and PGE2 in a Patient-Derived Colorectal Cancer Organoids Model

Investigators used their recently developed 3D dendritic cell (DC)-tumor co-culture system to investigate how patient-derived primary and metastatic colorectal cancer organoids modulated conventional DC type 2 (cDC2) phenotype and function.