Expression of USP25 Associates with Fibrosis, Inflammation and Metabolism Changes in IgG4-Related Disease

By using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), IgG4-RD cell lines, and Usp25 knockout mice, investigators showed that ubiquitin-specific protease 25 (USP25) engages in multiple pathways to regulate fibrotic and inflammatory pathways that are characteristic to IgG4-RD.