Prior Infection with Unrelated Neurotropic Virus Exacerbates Influenza Disease and Impairs Lung T Cell Responses

Researchers established a mouse model of co-infection with unrelated viruses, influenza A (IAV) and Semliki Forest virus (SFV), causing disease in different organ systems. SFV infection eight days before IAV infection results in prolonged IAV replication, elevated cytokine/chemokine levels and exacerbated lung pathology.