Quantification of Adaptive Immune Responses Against Protein Binding Interfaces in the Streptococcal M1 Protein

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Investigators used affinity-purification combined with quantitative mass spectrometry to examine the level of competition between antigen-specific antibodies and host-pathogen protein interaction networks using the M1 protein from Streptococcus pyogenes as a model system.
[Molecular & Cellular Proteomics]
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