Impact of CRISPR/HDR Editing versus Lentiviral Transduction on Long-Term Engraftment and Clonal Dynamics of HSPCs in Rhesus Macaques

To track the output and clonality of homology-directed repair-edited cells and to provide a comparison to lentivirally transduced HSCs in vivo, investigators developed a competitive rhesus macaque autologous transplantation model.