Gene Features of Tumor-Specific T Cells Relevant to Immunotherapy, Targeted Therapy and Chemotherapy in Lung Cancer

Researchers defined tumor-specific T cells and their features (TSTGs) by single-cell RNA sequencing. They applied LASSO regression to filter out the most survival-relevant TSTGs to form the Tumor-specific T cell score (TSTS). Immunological characteristics, enriched pathways, and mutation were evaluated in high- and low TSTS groups.