B Cell-Directed CAR-T Cell Therapy Activates CD8+ Cytotoxic CARneg Bystander T Cells in Non-Human Primates and Patients

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Researchers performed single-cell RNA-Seq on non-human primate and patient-derived T cells to identify the phenotypic and transcriptomic hallmarks of bystander activation of CARneg T cells following B cell targeted CAR-T cell therapy.
[Blood]
Abstract