B Cell-Directed CAR-T Cell Therapy Activates CD8⁺ Cytotoxic CARneg Bystander T Cells in Non-Human Primates and Patients

Researchers performed single-cell RNA-Seq on non-human primate and patient-derived T cells to identify the phenotypic and transcriptomic hallmarks of bystander activation of CARneg T cells following B cell targeted CAR-T cell therapy.