Non-Catalytic Role of Phosphoinositide 3-Kinase in Mesenchymal Cell Migration through Non-Canonical Induction of p85β/AP2-Mediated Endocytosis

Researchers reported that a disordered region of inter SH2 domain contained AP2 binding motifs which could trigger clathrin and dynamin-mediated endocytosis independent of PI3K catalytic activity.