Non-Catalytic Role of Phosphoinositide 3-Kinase in Mesenchymal Cell Migration through Non-Canonical Induction of p85β/AP2-Mediated Endocytosis

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Researchers reported that a disordered region of inter SH2 domain contained AP2 binding motifs which could trigger clathrin and dynamin-mediated endocytosis independent of PI3K catalytic activity.
[Nature Communications]
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