GFI1B and LSD1 Repress Myeloid Traits during Megakaryocyte Differentiation

Researchers studied transcriptomic effects of four patient-derived growth factor independence 1B (GFI1B) variants in MEG01 megakaryoblasts. Compared to normal GFI1B, each variant affected different gene programs with GFI1BQ287* uniquely failing to repress myeloid traits.