Nanomolar Anti-SARS-CoV-2 Omicron Activity of the Host-Directed TMPRSS2 Inhibitor N-0385 and Synergistic Action with Direct-Acting Antivirals

Investigators reported that human TMPRSS2 was a molecular determinant of viral entry for all the Omicron clinical isolates tested in human lung cells, including ancestral Omicron subvariants, contemporary Omicron subvariants and currently circulating Omicron BA.2.86.