Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells

Seven HDACi, showing either hydroxamate or 2′-aminoanilide function, were tested in colorectal cancer and glioblastoma multiforme CSCs to determine their effects on cell proliferation, H3 acetylation levels and in-cell HDAC activity.