NFĸB Signaling Drives Myocardial Injury via CCR2⁺ Macrophages in a Preclinical Model of Arrhythmogenic Cardiomyopathy

Researchers found that Nuclear factor kappa-B (NFκB) signaling in cardiac myocytes drives myocardial injury, contractile dysfunction, and arrhythmias in Dsg2mut/mut mice. NFκB signaling in cardiac myocytes mobilizes macrophages expressing C-C motif chemokine receptor-2 (CCR2+ cells) to affected areas within the heart, where they mediate myocardial injury and arrhythmias.